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Effect of intra-arterially induced alpha-receptor blockade upon resistance in collateral arteries in patients with occlusion of the superficial femoral artery.
- Source :
-
Clinical physiology (Oxford, England) [Clin Physiol] 1981 Aug; Vol. 1 (4), pp. 385-93. - Publication Year :
- 1981
-
Abstract
- The effect of intra-arterially phentolamine inducing alpha-receptor blockade upon the resistance in collateral arteries bypassing an occlusion of the femoral artery was studied in five patients. The patients were placed on a tilt table and the measurements were performed with the patients in supine position and titled 40 degrees (head-up). Arterial blood pressure was measured directly in the brachial-common femoral-and popliteal artery. Relative blood flow was calculated as the relative change in arterio-venous oxygen saturation. Head-up tilt caused a decrease in blood flow of about 35% corresponding to an increase in total vascular resistance of 38%. Resistance in collateral arteries increased by 45%. In supine position alpha-receptor blockade reduced collateral resistance by 17%. However, the title-induced constriction of the collateral arteries was blocked by 87%. The results indicate that the constriction of the collateral arteries bypassing an occlusion of the superficial femoral artery is mainly mediated via sympathetic adrenergic vasoconstrictor fibres.
- Subjects :
- Aged
Blood Flow Velocity
Humans
Middle Aged
Phentolamine administration & dosage
Phentolamine pharmacology
Phentolamine therapeutic use
Vasoconstriction drug effects
Adrenergic alpha-Antagonists pharmacology
Arterial Occlusive Diseases drug therapy
Collateral Circulation drug effects
Femoral Artery
Vascular Resistance drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0144-5979
- Volume :
- 1
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinical physiology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 6120777
- Full Text :
- https://doi.org/10.1111/j.1475-097x.1981.tb00906.x