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The absence of unique kainic acid-like molecules in urine, serum, and CSF from Huntington's disease patients.

Authors :
Beutler BA
Noronha AB
Poon MM
Arnason BG
Source :
Journal of the neurological sciences [J Neurol Sci] 1981 Sep; Vol. 51 (3), pp. 355-60.
Publication Year :
1981

Abstract

By means of a sensitive competition assay, serum, urine, and CSF from patients with Huntington's disease (HD) and controls were tested for the presence of molecules capable of displacing radioactive kainic acid (KA) from rat brain receptors. No difference was found between HD and control samples. It is unlikely that systemic production of an endogenous toxin structurally related to KA occurs in HD.

Details

Language :
English
ISSN :
0022-510X
Volume :
51
Issue :
3
Database :
MEDLINE
Journal :
Journal of the neurological sciences
Publication Type :
Academic Journal
Accession number :
6115893
Full Text :
https://doi.org/10.1016/0022-510x(81)90113-1