A probable neuroleptic effect on platelet monoamine oxidase in chronic schizophrenic patients.

Authors :: DeLisi LE
Wise CD
Bridge TP
Rosenblatt JE
Wagner RL
Morihisa J
Karson C
Potkin SG
Wyatt RJ
Source :: Psychiatry research [Psychiatry Res] 1981 Feb; Vol. 4 (1), pp. 95-107.
Publication Year :: 1981
Abstract: Platelet monoamine oxidase activity (MAO) was studied serially over time in 16 chronic schizophrenic patients when medication free and then when medicated. Thirteen of the 16 patients had significant decreases in platelet MAO activity following neuroleptic drug treatment. The change in MAO activity was found to be correlated with response to treatment and to dose of medication.

Subjects :: Adult
Chronic Disease
Depression, Chemical
Female
Fluphenazine therapeutic use
Haloperidol therapeutic use
Humans
Male
Trifluoperazine therapeutic use
Antipsychotic Agents therapeutic use
Blood Platelets enzymology
Monoamine Oxidase blood
Schizophrenia drug therapy

Full Text Access

Tools