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Leukotriene E4 causes pulmonary vasoconstriction, not inhibited by meclofenamate.
- Source :
-
Prostaglandins [Prostaglandins] 1983 Dec; Vol. 26 (6), pp. 869-83. - Publication Year :
- 1983
-
Abstract
- Leukotriene E4 (LTE4) appears to be a rather stable product of the lipoxygenase pathway. Its action in the pulmonary circulation is unknown. Therefore we investigated its effect on the circulation of isolated rat lungs perfused with a cell- and plasma-free solution. Synthetic LTE4 in doses from .15 micrograms to 5 micrograms/.25 ml .9% NaCl injected as a bolus in the pulmonary artery during normoxia caused a fast, transient perfusion pressure increase within seconds. This was followed by a slow rise in baseline perfusion pressure (normoxia) over 25 min. In addition, 5 micrograms LTE4 caused edematogenic lung damage. Injection of 1.5 micrograms LTE4 during hypoxic vasoconstriction caused fast, transient pressure rises, similar to normoxic conditions. 6-keto-PGF1 alpha and TXB2 were measured in the lung effluent before and after LTE4 injection. Neither 6-keto-PGF1 alpha nor TXB2 production changed after LTE4 injection. Meclofenamate (.5 micrograms/ml) increased the fast, transient and the slow, sustained pressure rise. We conclude that LTE4 caused direct pulmonary vasoconstriction unrelated to cyclooxygenase products.
- Subjects :
- 6-Ketoprostaglandin F1 alpha metabolism
Animals
Blood Pressure
Isoproterenol pharmacology
Leukotriene E4
Male
Pulmonary Artery physiology
Rats
Rats, Inbred Strains
SRS-A pharmacology
Thromboxane B2 metabolism
Lung blood supply
Meclofenamic Acid pharmacology
SRS-A analogs & derivatives
Vasoconstriction drug effects
ortho-Aminobenzoates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0090-6980
- Volume :
- 26
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Prostaglandins
- Publication Type :
- Academic Journal
- Accession number :
- 6098932
- Full Text :
- https://doi.org/10.1016/0090-6980(83)90150-8