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Effect of urinary alkalinization on renal changes produced by cationic albumin.

Authors :
Coimbra TM
DeGiacobbi G
Gouveia MA
Lachat JJ
De Carvalho IF
Source :
Nephron [Nephron] 1984; Vol. 38 (4), pp. 261-6.
Publication Year :
1984

Abstract

40-mg doses of human cationic (CA) or anionic (AA) albumin were administered intravenously to 48 normal female rats. Sodium bicarbonate (NaHCO3) was administered to 8 of these animals before CA or AA. Urine alkalinization caused increased renal CA excretion in CA-injected animals, which also showed marked reduction of the intensity of the renal changes produced by CA.

Subjects

Subjects :
Animals
Cations
Female
Hydrogen-Ion Concentration
Kidney Tubules, Proximal ultrastructure
Rats
Rats, Inbred Strains
Sodium Bicarbonate
Urine
Albumins toxicity
Albuminuria chemically induced
Bicarbonates pharmacology
Kidney Tubules, Proximal drug effects

Details

Language :
English
ISSN :
1660-8151
Volume :
38
Issue :
4
Database :
MEDLINE
Journal :
Nephron
Publication Type :
Academic Journal
Accession number :
6096744
Full Text :
https://doi.org/10.1159/000183320
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