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Carcinoembryonic antigen (CEA) levels in pleural effusions and sera of lung cancer patients.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 1984 Sep; Vol. 14 (3), pp. 321-7. - Publication Year :
- 1984
-
Abstract
- For determining the value of carcinoembryonic antigen (CEA) levels in diagnosis of malignant tumors of the lung, the CEA levels in 187 specimens of pleural fluid and sera obtained simultaneously from patients with pleural fluid were measured. In all 70 patients with benign diseases, the CEA levels in the effusions were less than the cut-off value of 5 ng/ml (mean +/- SD: 1.44 +/- 1.01 ng/ml). In contrast, in 88 of 117 patients (75.2%) with malignant diseases, the CEA levels in the effusions were over 5 ng/ml (25.3 +/- 24.5 ng/ml) and in 58 of the 117 patients (50.4%), the CEA levels in the serum were values of 5 ng/ml or more (11.9 +/- 18.4 ng/ml). There was a significant correlation between the CEA levels in the effusions and in the sera. The CEA levels in effusions in patients with malignant lung tumors were usually much higher than those in their sera. The incidence of CEA levels of 5 ng/ml or more in both the serum and effusion was highest in the patients with adenocarcinoma. These data indicate that determination of the CEA level in effusions, when done in combination with cytological examinations, may have additional value in diagnosis of lung cancer.
- Subjects :
- Adenocarcinoma immunology
Adult
Aged
Carcinoma, Small Cell immunology
Carcinoma, Squamous Cell immunology
Diagnosis, Differential
Female
Humans
Lung Diseases immunology
Lung Neoplasms diagnosis
Male
Middle Aged
Pleurisy immunology
Carcinoembryonic Antigen analysis
Lung Neoplasms immunology
Pleural Effusion immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0368-2811
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 6090732