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Bacterial flora of the small intestine and bile acid metabolism in patients with hepatico-jejunostomy Roux-en-Y.

Authors :
Nielsen ML
Justesen T
Lenz K
Nielsen OV
Jensen SL
Source :
Scandinavian journal of gastroenterology [Scand J Gastroenterol] 1977; Vol. 12 (8), pp. 977-82.
Publication Year :
1977

Abstract

Duodenal and jejunal bacterial flora and bile acid metabolism were investigated in 14 patients with hepatico-jejunostomy Roux-en-Y. Anaerobic culture procedures were based on the use of a glove-box with an oxygen-free atmosphere and pre-reduced, anaerobically sterilized media. Anaerobic transport was based on evacuation of atmospheric air from transport-tubes and transport-time less than 30 minutes. Bile acid metabolism was evaluated from concentrations of toal bile acids and deconjugated bile acids, glycine/taurine ratio and breath test. In 92 per cent of the patients an abnormal flora-containing anaerobic and/or aerobic bacteria was found in the most proximal part of the jejunum at the site of the entero-entero anastomosis (cf. Fig. 1 and Table 1). Total bile acid concentrations were low in half of the patients, whereas deconjugated bile acids or elevated glycine/taurine ratio was found in one patient only (cf. Table II). An abnormal breath test was found in 5 patients, but without any clear correlation between the breath test and the bacterial flora.

Details

Language :
English
ISSN :
0036-5521
Volume :
12
Issue :
8
Database :
MEDLINE
Journal :
Scandinavian journal of gastroenterology
Publication Type :
Academic Journal
Accession number :
605357
Full Text :
https://doi.org/10.3109/00365527709181360