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Effects of diazepam on succinylcholine-induced myalgia, potassium increase, creatine phosphokinase elevation, and relaxation.
- Source :
-
Anesthesia and analgesia [Anesth Analg] 1979 Jul-Aug; Vol. 58 (4), pp. 314-7. - Publication Year :
- 1979
-
Abstract
- Diazepam in a dose of 0.05 mg/kg was studied to determine its effect on a subsequently administered dose of 1 mg/kg of succinylcholine. This dose of diazepam prior to succinylcholine (1) significantly diminished the incidence of postoperative muscle pain; (2) decreased the usual increase in serum potassium; (3) did not prevent the rise in creatine phosphokinase; (4) reduced the incidence of muscle fasciculation; and (5) did not affect the magnitude or duration of the succinylcholine neuromuscular block. It was concluded that diazepam had several advantages over d-tubocurarine in the prevention of succinylcholine-induced muscle pain.
- Subjects :
- Female
Humans
Male
Muscles drug effects
Tubocurarine pharmacology
Creatine Kinase blood
Diazepam pharmacology
Muscle Contraction drug effects
Muscle Relaxation drug effects
Muscular Diseases chemically induced
Pain, Postoperative chemically induced
Potassium blood
Succinylcholine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0003-2999
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Anesthesia and analgesia
- Publication Type :
- Academic Journal
- Accession number :
- 572176
- Full Text :
- https://doi.org/10.1213/00000539-197907000-00011