Synthesis and biological activity of (2-hydroxy-1-naphthyl)-methylamino acetamido-epicillin and cephradine, and (2-hydroxy-1-naphthyl)-methylacetamido 6-APA.

Authors :: Ryu DD
Mukherjee BB
Lee BK
Source :: The Journal of antibiotics [J Antibiot (Tokyo)] 1977 Jan; Vol. 30 (1), pp. 66-70.
Publication Year :: 1977
Abstract: Two new penicillins and a new cephalosporin have been synthesized by condensing 2-hydroxy-1-naphthaldehyde with epicillin, 6-aminopenicillanic acid and cephradine, and subsequently reducing the SCHIFF bases with NaBH4. The antimicrobial activities of these compounds are also described.

Subjects :: Ampicillin blood
Ampicillin chemical synthesis
Ampicillin pharmacology
Animals
Bacteria drug effects
Cephradine analogs & derivatives
Cephradine blood
Cephradine pharmacology
Mice
Penicillins blood
Penicillins pharmacology
Staphylococcal Infections drug therapy
Ampicillin analogs & derivatives
Cephalosporins chemical synthesis
Cephradine chemical synthesis
Penicillins chemical synthesis

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