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Failure of somatostatin to correct manifest diabetic ketoacidosis.
- Source :
-
Lancet (London, England) [Lancet] 1976 Jan 31; Vol. 1 (7953), pp. 215-8. - Publication Year :
- 1976
-
Abstract
- Juvenile diabetic patients were studied 60-72 hours after insulin withdrawal when moderate ketoacidosis had developed. Somatostatin infusion for 4 hours in five patients resulted in almost complete suppression of plasma pancreatic glucagon and growth hormone, a fall in plasma-cyclic-adenosine-monophosphate (A.M.P.) concentrations, and a large fall in plasma-glucose concentration. After infusion plasma concentrations of these substances rose again. Blood-ketone-bodies, plasma-free-fatty-acids (F.F.A.), and plasma glycerol concentrations, however, did not decrease appreciably with somatostatin administration. In three patients 2 to 3 h somatostatin infusions were twice superimposed upon a continuous 9-5 h insulin infusion (1 unit/h). An insulin effect was noticeable within 30 minutes, with pronounced falls in the concentrations of plasma glucose, pancreatic glucagon, F.F.A., and blood-ketone-bodies. There was no significant change in these patterns when somatostatin was administered or withdrawn. These results do not indicate that somatostatin infusion would be useful in the treatment of manifest diabetic ketoacidosis.
- Subjects :
- Adult
Blood Glucose analysis
Cyclic AMP blood
Diabetic Ketoacidosis blood
Drug Evaluation
Fatty Acids, Nonesterified blood
Female
Glucagon blood
Growth Hormone blood
Humans
Hydrocortisone blood
Infusions, Parenteral
Insulin administration & dosage
Ketone Bodies blood
Male
Somatostatin administration & dosage
Diabetes Mellitus, Type 1 complications
Diabetic Ketoacidosis drug therapy
Somatostatin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0140-6736
- Volume :
- 1
- Issue :
- 7953
- Database :
- MEDLINE
- Journal :
- Lancet (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 55530
- Full Text :
- https://doi.org/10.1016/s0140-6736(76)91338-6