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Phosphoribosyl transferase activity in normal subjects, gout patients, and children with mental retardation.
- Source :
-
Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 1971 Feb; Vol. 34 (1), pp. 23-4. - Publication Year :
- 1971
-
Abstract
- Activity of hypoxanthine-guanine and adenine phosphoribosyl transferase enzymes has been assayed in erythrocytes from 10 normal adults, 37 subjects with gout, and 21 mentally retarded children with high and normal urinary uric acid:creatinine ratios. These were compared with one case of known HGPRTase deficiency. Apart from the last subject, no cases of HGPRTase deficiency were found.
- Subjects :
- Adenine
Adolescent
Adult
Child
Child, Preschool
Creatinine urine
Erythrocytes enzymology
Female
Gout blood
Guanine
Humans
Hypoxanthines
Intellectual Disability blood
Male
Radiochemistry
Uric Acid analysis
Gout enzymology
Intellectual Disability enzymology
Metabolism, Inborn Errors enzymology
Transferases blood
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3050
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 5551690
- Full Text :
- https://doi.org/10.1136/jnnp.34.1.23