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Chemotherapeutic alteration of small intestinal morphology and function: a progress report.
- Source :
-
Journal of clinical gastroenterology [J Clin Gastroenterol] 1979 Sep; Vol. 1 (3), pp. 203-7. - Publication Year :
- 1979
-
Abstract
- Nine patients with malignancy requiring chemotherapy were evaluated before, during, and in the recovery phase of their antineoplastic regimen with selected absorptive studies and jejunal biopsies. Depression of the crypt mitoses occurred without change in the indices of absorption. The mitotic indices returned to pretreatment counts on the recovery phase biopsies. Even after prolonged therapy, restudy in three of the patients failed to demonstrate clinical malabsorption. We conclude that chemotherapy-related malabsorption does not contribute to overall malnutrition of cancer patients during the first months of treatment.
- Subjects :
- Antineoplastic Agents therapeutic use
Epithelium drug effects
Humans
Intestine, Small pathology
Intestine, Small physiopathology
Mitotic Index
Neoplasms drug therapy
Antineoplastic Agents pharmacology
Intestinal Absorption drug effects
Intestine, Small drug effects
Neoplasms physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0192-0790
- Volume :
- 1
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of clinical gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 553095
- Full Text :
- https://doi.org/10.1097/00004836-197909000-00003