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Chemotherapeutic alteration of small intestinal morphology and function: a progress report.

Authors :
Smith FP
Kisner DL
Widerlite L
Schein PS
Source :
Journal of clinical gastroenterology [J Clin Gastroenterol] 1979 Sep; Vol. 1 (3), pp. 203-7.
Publication Year :
1979

Abstract

Nine patients with malignancy requiring chemotherapy were evaluated before, during, and in the recovery phase of their antineoplastic regimen with selected absorptive studies and jejunal biopsies. Depression of the crypt mitoses occurred without change in the indices of absorption. The mitotic indices returned to pretreatment counts on the recovery phase biopsies. Even after prolonged therapy, restudy in three of the patients failed to demonstrate clinical malabsorption. We conclude that chemotherapy-related malabsorption does not contribute to overall malnutrition of cancer patients during the first months of treatment.

Details

Language :
English
ISSN :
0192-0790
Volume :
1
Issue :
3
Database :
MEDLINE
Journal :
Journal of clinical gastroenterology
Publication Type :
Academic Journal
Accession number :
553095
Full Text :
https://doi.org/10.1097/00004836-197909000-00003