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Chloride-dependent restoration of coupling by oligomycin in rat liver mitochondria.
- Source :
-
The Biochemical journal [Biochem J] 1975 Oct; Vol. 152 (1), pp. 115-9. - Publication Year :
- 1975
-
Abstract
- In rat liver mitochondria suspended in KC1 medium, oligomycin interfered with the effect of uncouplers on energy conservation. It antagonized the effect of uncouplers that are weak acids (2,4-dinitrophenol etc.), but enhanced that of the lipid-penetrating cation NN-dimethyl-N'N'-dibenzylammonium. Oligomycin caused none of the above effects when Br- or NO-/3 was substituted for C1- as the major anionic species in the assay medium. The concentration of oligomycin that exerted the above-mentioned effects was lower than that necessary for the inhibition of energy transfer, but was in the range that induced C1- permeation through the cristae membrane. The possible connexion between the effect of oligomycin on C1- permeation and its interference with the action of uncouplers is discussed.
- Subjects :
- Adenosine Diphosphate pharmacology
Adenosine Triphosphatases analysis
Animals
Bromides metabolism
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone antagonists & inhibitors
Dicumarol antagonists & inhibitors
Dinitrophenols antagonists & inhibitors
Dinitrophenols pharmacology
Mitochondria, Liver drug effects
Mitochondrial Swelling drug effects
Nitrates metabolism
Oxidative Phosphorylation drug effects
Oxygen Consumption drug effects
Quaternary Ammonium Compounds antagonists & inhibitors
Rats
Chlorides metabolism
Mitochondria, Liver metabolism
Oligomycins pharmacology
Uncoupling Agents antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0264-6021
- Volume :
- 152
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Biochemical journal
- Publication Type :
- Academic Journal
- Accession number :
- 55121
- Full Text :
- https://doi.org/10.1042/bj1520115