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The influence of genotype on the development of glomerular lesions in mink with Aleutian disease virus.
- Source :
-
The American journal of pathology [Am J Pathol] 1975 Nov; Vol. 81 (2), pp. 321-36. - Publication Year :
- 1975
-
Abstract
- In an attempt to document progression rate differences in the development of glomerular lesions in mink infected with Aleutian disease virus (ADV), the glomeruli of Aleutian and non-Aleutian mink experimentally infected with ADV were evaluated by light, fluorescent, and electron microscopy. The animals were also examined for the presence of interstitial infiltrate, neutrophils, and arterial lesions. One hundred percent of the Aleutian mink had glomerular cell proliferation and interstitial infiltrate, while 95% of the Aleutian and 41% of the non-Aleutian mink had neutrophilic infiltrates and arteritis, respectively. Of the non-Aleutian mink, 91, 83, 42, and 12.5% had glomerular cell proliferations, glomerular neutrophils, interstitial infiltrate, and arterial lesions in, that order. All the Aleutian mink had glomerular depositions of gamma-globulin (IgG) and complement (C3), whereas 75% of non-Aleutian mink had deposits of IgG and C3. One hundred percent of both genotypes had glomerular deposits of immunoglobulin M (IgM). Ultrastructural glomerular changes consisting primarily of depositions of granular electron-dense material on basement membranes were observed in Aleutian mink 6 weeks after infection and 12 weeks after infection in non-Aleutian mink. These findings document progression rate differences in the development of glomerular lesions in Aleutian disease-affected Aleutian and non-Aleutian mink. Further, they emphasize the need for exploration of pathogenetic mechanisms involved in progression rate differences in lesion development.
- Subjects :
- Aleutian Mink Disease genetics
Aleutian Mink Disease immunology
Animals
Complement C3 analysis
Immunoglobulin M analysis
Kidney ultrastructure
Kidney Glomerulus analysis
Species Specificity
gamma-Globulins analysis
Aleutian Mink Disease pathology
Aleutian Mink Disease Virus immunology
Genotype
Kidney pathology
Mink immunology
Viruses, Unclassified immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9440
- Volume :
- 81
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 53016