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Controlled field trial of the effectiveness of cholera and cholera El Tor vaccines in Calcutta.
- Source :
-
Bulletin of the World Health Organization [Bull World Health Organ] 1967; Vol. 37 (3), pp. 371-85. - Publication Year :
- 1967
-
Abstract
- To assess the effectiveness of cholera vaccines, 2 controlled field trials were made in Calcutta-an endemic area-during 1964 and 1965. Three Indian vaccines of which 1 was grown on casein hydrolysate and 2 on agar, a freeze-dried vaccine from the Walter Reed Army Institute of Research (WRAIR), Washington, D.C., and an El Tor vaccine from the Philippines were used, with typhoid-paratyphoid (TAB) vaccine as a control. The 210 112 volunteers were vaccinated subcutaneously with a single dose of one of the vaccines.In the 1964 trial, the number of bacteriologically confirmed cases was not enough to show statistically significant differences in incidence between the 5 vaccine groups and the control group. However, the WRAIR freeze-dried vaccine protected about 40% of the vaccinees for 6 months after vaccination, although the efficacy was higher (57%) during the first 3 months than during the subsequent 3 months (28%). Agar-grown vaccine, produced by the Central Research Institute, Kasauli, was 37% efficacious.In the 1965 trial, owing to the small number of cases in the study area, the Kasauli vaccine was the only one to show statistically significant protection (40%).
Details
- Language :
- English
- ISSN :
- 0042-9686
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bulletin of the World Health Organization
- Publication Type :
- Academic Journal
- Accession number :
- 5301381