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Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings.

Authors :
Pearson RM
Griffith DN
Woollard M
James IM
Havard CW
Source :
British journal of clinical pharmacology [Br J Clin Pharmacol] 1979; Vol. 8 (Suppl 2), pp. 195S-198S.
Publication Year :
1979

Abstract

1 Diazoxide 300 mg and labetalol 150 mg were each injected intravenously on separate occasions into five patients with essentail hypertension. The reduction in BP caused by labetalol was slightly greater than that produced by diazoxide. 2 In contrast the reduction in cerebral blood flow (CBF) by labetalol was not statistically significant, whereas diazoxide gave a greater and statistically significant reduction in CBF. 3 These observations suggest that labetalol may have an advantage over diazoxide for the rapid reduction in BP.

Details

Language :
English
ISSN :
0306-5251
Volume :
8
Issue :
Suppl 2
Database :
MEDLINE
Journal :
British journal of clinical pharmacology
Publication Type :
Academic Journal
Accession number :
526401