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Alteration in microsomal protein synthesis during early development of mouse brain.

Alteration in microsomal protein synthesis during early development of mouse brain.

Authors :
Johnson TC
Belytschko G
Source :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1969 Mar; Vol. 62 (3), pp. 844-51.
Publication Year :
1969

Abstract

The loss of protein synthesis during early mouse-brain development was shown to be the result, at least in part, of the inability of microsomes obtained from more mature neural tissue to participate in rapid polypeptide synthesis. The loss of brain microsomal activity was observed shortly after birth and continued until the animals were approximately ten days old. Despite the difference in synthetic activity, sucrose gradient profiles of microsomes and polyribosomes from young and more mature brain tissue were quite similar. The loss in protein synthesis was shown to be independent of available mRNA and not attributable to aminoacyl-RNA synthetases and tRNA binding activity.

Details

Language :
English
ISSN :
0027-8424
Volume :
62
Issue :
3
Database :
MEDLINE
Journal :
Proceedings of the National Academy of Sciences of the United States of America
Publication Type :
Academic Journal
Accession number :
5257009
Full Text :
https://doi.org/10.1073/pnas.62.3.844