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Cold blood as the vehicle for potassium cardioplegia.
- Source :
-
The Annals of thoracic surgery [Ann Thorac Surg] 1979 Dec; Vol. 28 (6), pp. 509-21. - Publication Year :
- 1979
-
Abstract
- Cold blood with potassium, 34 mEq/L, was compared with cold blood and with a cardioplegic solution. Three groups of 6 dogs had 2 hours of aortic cross-clamp while on total bypass at 28 degrees C with the left ventricle vented. An initial 5-minute coronary perfusion was followed by 2 minutes of perfusion every 15 minutes for the cardioplegic solution (8 degrees C) and every 30 minutes for 3 minutes with cold blood or cold blood with potassium (8 degrees C). Hearts receiving cold blood or cold blood with potassium had topical cardiac hypothermia with crushed ice. Peak systolic pressure, rate of rise of left ventricular pressure, maximum velocity of the contractile element, pressure volume curves, coronary flow, coronary flow distribution, and myocardial uptake of oxygen, lactate, and pyruvate were measured prior to ischemia and 30 minutes after restoration of coronary flow. Myocardial creatine phosphate (CP), adenosine triphosphate (ATP), and adenosine diphosphate (ADP) were determined at the end of ischemia and after recovery. Changes in coronary flow, coronary flow distribution, and myocardial uptake of oxygen and pyruvate were not significant. Peak systolic pressure and lactate uptake declined significantly for hearts perfused with cold blood but not those with cold blood with potassium. ATP and ADP were lowest in hearts perfused with cardioplegic solution, and CP and ATP did not return to control in any group. Heart water increased with the use of cold blood and cardioplegic solution. Myocardial protection with cold blood with potassium and topical hypothermia has some advantages over cold blood and cardioplegic solution.
- Subjects :
- Adenosine Diphosphate metabolism
Adenosine Triphosphate metabolism
Animals
Cold Temperature
Coronary Disease metabolism
Coronary Disease pathology
Coronary Disease physiopathology
Dogs
Glycolysis
Heart Ventricles physiopathology
Hemodynamics
Myocardium metabolism
Myocardium ultrastructure
Perfusion
Phosphocreatine metabolism
Potassium
Blood
Cardiopulmonary Bypass
Heart Arrest, Induced methods
Hypothermia, Induced methods
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4975
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Annals of thoracic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 518180
- Full Text :
- https://doi.org/10.1016/s0003-4975(10)63171-2