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Formation of malate from glyoxylate in animal tissues.

Authors :
Liang CC
Ou LC
Source :
The Biochemical journal [Biochem J] 1971 Feb; Vol. 121 (3), pp. 447-52.
Publication Year :
1971

Abstract

1. Incubation of rat liver homogenate with [1-(14)C]glyoxylate, ATP and acetate shows a rapid sequential incorporation of radioactivity into malate, oxaloacetate and citrate. 2. In liver from normal rats the rate of the formation of each substance in question is higher than that in liver from thiamin-deficient rats. 3. The net accumulation of malate is greater with liver from thiamin-deficient rats. Its further metabolism is retarded, it is suggested, by inhibitors formed by a condensation of glyoxylate and oxaloacetate.

Subjects

Subjects :
Acetates metabolism
Adenosine Triphosphate metabolism
Animals
Carbon Isotopes
Chromatography, Paper
Citrates biosynthesis
Female
In Vitro Techniques
Male
Oxaloacetates biosynthesis
Rats
Thiamine Deficiency metabolism
Glyoxylates metabolism
Liver metabolism
Malates biosynthesis

Details

Language :
English
ISSN :
0264-6021
Volume :
121
Issue :
3
Database :
MEDLINE
Journal :
The Biochemical journal
Publication Type :
Academic Journal
Accession number :
5119782
Full Text :
https://doi.org/10.1042/bj1210447
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