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A new experimental model of human cachexia.
- Source :
-
Investigative & cell pathology [Invest Cell Pathol] 1979 Apr-Jun; Vol. 2 (2), pp. 87-96. - Publication Year :
- 1979
-
Abstract
- A hypernephroma removed from a male patient who had lost 30 kg in weight in the two months preceding surgery was grown as a non-metastasizing transplantable xenograft in immune-suppressed mice. The tumour produced a considerable weight loss (greater than 25 per cent) in the mice at a stage when it comprised less than 5 per cent of the total body weight. A slight fall in food intake of the tumour-bearing mice was noted, but animals bearing other non-cachectic mouse and human tumours had much lower food intakes without accompanying weight loss. No obvious defects in gastrointestinal absorption were detected nor was any gross increase in basal metabolic rate observed. The precise mechanism producing the severe cachexia remains to be established, but elaboration of humoral factors by the tumour seems probable. This model of cachexia bears a closer relation to the clinical situation than do other experimental animal tumour models currently available.
- Subjects :
- Adenocarcinoma complications
Adenocarcinoma physiopathology
Animals
Body Composition
Cachexia physiopathology
Energy Intake
Female
Intestinal Absorption
Male
Mice
Neoplasm Transplantation
Neoplasms, Experimental complications
Neoplasms, Experimental physiopathology
Cachexia etiology
Disease Models, Animal
Subjects
Details
- Language :
- English
- ISSN :
- 0146-7611
- Volume :
- 2
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Investigative & cell pathology
- Publication Type :
- Academic Journal
- Accession number :
- 511610