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Noradrenaline producing phaeochromocytomas with absent pressor response to beta-blockade.
- Source :
-
British heart journal [Br Heart J] 1979 Sep; Vol. 42 (3), pp. 359-61. - Publication Year :
- 1979
-
Abstract
- In 2 patients with phaeochromocytoma, effective beta-blockade was obtained with propranolol (40 mg twice a day for 3 days) or acebutolol (400 mg twice a day for 3 days) without any effect on the blood pressure. In both patients the excretion of noradrenaline predominated over that of adrenaline, a picture found in most cases of phaeochromocytoma. A hypertensive response to beta-blockade might be expected in patients with an adrenaline-secreting tumour. It cannot be a regular event or constitute a diagnostic test in patients with suspected phaeochromocytoma.
- Subjects :
- Adrenal Gland Neoplasms physiopathology
Adult
Female
Heart Rate drug effects
Humans
Male
Middle Aged
Pheochromocytoma physiopathology
Renin blood
Acebutolol pharmacology
Adrenal Gland Neoplasms metabolism
Blood Pressure drug effects
Norepinephrine metabolism
Pheochromocytoma metabolism
Propranolol pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0769
- Volume :
- 42
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 508460
- Full Text :
- https://doi.org/10.1136/hrt.42.3.359