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The treatment of postperfusion bleeding using epsilon-aminocaproic acid, cryoprecipitate, fresh-frozen plasma, and protamine sulfate.
- Source :
-
The Annals of thoracic surgery [Ann Thorac Surg] 1979 Nov; Vol. 28 (5), pp. 440-4. - Publication Year :
- 1979
-
Abstract
- The evaluation of excessive hemorrhage was carried out in 774 patients after cardiopulmonary bypass. Excessive hemorrhage was defined in any adult patient as chest tube drainage of more than 600 ml within the first eight hours after operation. Using the prothrombin time, partial thromboplastin time, fibrinogen level, and tri-F titer tests, it was possible to differentiate medical from surgical bleeding. Hyperfibrinolytic bleeding was the most frequently identifiable coagulation disorder and occurred in 159 patients (20%). All these patients were successfully treated with Amicar (epsilon-aminocaproic acid) alone, or with Amicar supplemented with cryoprecipitate or fresh-frozen plasma. Three patients (0.4%) were noted to have residual heparin and required additional protamine sulfate. Five patients (0.6%) had normal coagulation studies and required immediate reexploration. The overall blood consumption per patient was 2.1 units of packed cells. Whole blood and platelets were not used.
- Subjects :
- Aminocaproic Acid administration & dosage
Erythrocytes
Fibrinolysis
Hemorrhage etiology
Humans
Plasma
Protamines administration & dosage
Aminocaproates therapeutic use
Aminocaproic Acid therapeutic use
Blood Transfusion
Cardiopulmonary Bypass adverse effects
Hemorrhage therapy
Postoperative Complications therapy
Protamines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4975
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Annals of thoracic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 496496
- Full Text :
- https://doi.org/10.1016/s0003-4975(10)63153-0