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A comparative study of the effects of carbon dioxide and perfusion rewarming on limited circulatory occlusion during surface hypothermia, under halothane and ether anesthesia.
A comparative study of the effects of carbon dioxide and perfusion rewarming on limited circulatory occlusion during surface hypothermia, under halothane and ether anesthesia.
- Source :
-
Annals of surgery [Ann Surg] 1974 Aug; Vol. 180 (2), pp. 192-7. - Publication Year :
- 1974
-
Abstract
- Effects of the use of 5% CO(2) and surface-rewarming or perfusion- rewarming on safe total circulatory occlusion time, blood gases and carbohydrate metabolism were studied in 25 dogs subjected to surface hypothermia (18 C) and 30 minutes of circulatory occlusion under halothane or ether anesthesia. Under halothane anesthesia, all animals with 100% 0(2) developed motor disorders while one of five surface-rewarmed dogs and none of the perfusion-rewarmed dogs developed motor disorders with 5% CO(2). Under ether anesthesia, all were normal with either 100% 0(2) or when 5% CO(2) was added. Ventricular fibrillation occurred in one dog at 21C under halothane anesthesia with 5% CO(2). Blood lactate levels remained low through hypothermic procedures when 5% CO(2) was used. Perfusion rewarming had little effect on lactate levels. The use of 100% 0(2) resulted in slightly higher lactate levels, especially in the ether anesthetized group, but these levels still remained within the upper limit of the normal range. Significant differences in lactate levels between halothane and ether anesthesia suggest different mechanisms of tissue circulation and metabolism during hypothermia. Halothane anesthesia can be useful with the use of CO(2) for surface hypothermia with 30 minutes circulatory occlusion but is still inferior to ether.
- Subjects :
- Anesthesia, Inhalation
Animals
Blood
Blood Glucose analysis
Body Temperature drug effects
Carbon Dioxide blood
Dogs
Follow-Up Studies
Gait
Heating
Humans
Hydrogen-Ion Concentration
Ischemia
Lactates blood
Oxygen blood
Postoperative Complications
Psychomotor Disorders chemically induced
Ventricular Fibrillation chemically induced
Carbon Dioxide pharmacology
Ethyl Ethers
Halothane
Heart Arrest, Induced
Hypothermia, Induced
Perfusion
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4932
- Volume :
- 180
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 4858391
- Full Text :
- https://doi.org/10.1097/00000658-197408000-00011