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Screening for carriers of Tay-Sachs disease: A community project.
- Source :
-
Canadian Medical Association journal [Can Med Assoc J] 1974 Aug 03; Vol. 111 (3), pp. 229-33. - Publication Year :
- 1974
-
Abstract
- Heterozygotes for Tay-Sachs disease can be distinguished by measuring the serum hexosaminidase activity and calculating the percentage of the heat-labile (A) form. We tested 7565 Ashkenazi Jews in Metropolitan Toronto and found a carrier frequency of 0.071. This figure was similar to the predicted frequency on the basis of caseload over a five-year period. We also found that 15% of women taking oral contraceptives were false-positive carriers. As with pregnant women, these false-positive carriers could be distinguished from true carriers by assaying leukocyte hexosaminidases.
- Subjects :
- Adult
Contraceptives, Oral
Costs and Cost Analysis
Facility Design and Construction
False Positive Reactions
Female
Health Education
Heterozygote
Hexosaminidases blood
Hot Temperature
Humans
Jews
Leukocytes analysis
Male
Methods
Ontario
Pregnancy
Volunteers
Lipidoses prevention & control
Mass Screening
Subjects
Details
- Language :
- English
- ISSN :
- 0008-4409
- Volume :
- 111
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Canadian Medical Association journal
- Publication Type :
- Academic Journal
- Accession number :
- 4854206