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The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.
- Source :
-
British journal of cancer [Br J Cancer] 1973 Oct; Vol. 28 (4), pp. 316-21. - Publication Year :
- 1973
-
Abstract
- Walker carcinosarcoma cells cause in vitro osteolysis which may be inhibited by aspirin. In the rat, this tumour produces osteolytic bone deposits and hypercalcaemia, both of which can be prevented by aspirin and indomethacin, whereas soft tissue tumour deposits are unaffected by these drugs. Some human breast tumours cause in vitro osteolysis which may be inhibited by aspirin.
- Subjects :
- Animals
Bone Neoplasms drug therapy
Bone and Bones metabolism
Calcium metabolism
Calcium Radioisotopes
Female
Humans
Hydrogen-Ion Concentration
Lactates pharmacology
Mice
Mice, Inbred BALB C
Time Factors
Aspirin pharmacology
Bone Resorption drug effects
Breast Neoplasms drug therapy
Carcinoma 256, Walker drug therapy
Hypercalcemia prevention & control
Indomethacin pharmacology
Neoplasm Metastasis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0920
- Volume :
- 28
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 4759939
- Full Text :
- https://doi.org/10.1038/bjc.1973.154