Naphthothiophenes. 4. Preparation of multisubstituted 4-naphtho(2,1-b)thiophenemathanols and the effect of side chain modification on antimalarial activity of 8-trifluoromethyl-4-naphtho(2,1-b)thiophenemethanols.

Authors :: Das BP
Nuss ME
Boykin DW Jr
Source :: Journal of medicinal chemistry [J Med Chem] 1974 May; Vol. 17 (5), pp. 516-9.
Publication Year :: 1974

Subjects :: Animals
Antimalarials therapeutic use
Hydrocarbons, Fluorinated chemical synthesis
Hydrocarbons, Fluorinated therapeutic use
Malaria drug therapy
Methanol chemical synthesis
Methanol therapeutic use
Mice
Naphthalenes chemical synthesis
Naphthalenes therapeutic use
Plasmodium berghei
Structure-Activity Relationship
Thiophenes therapeutic use
Antimalarials chemical synthesis
Thiophenes chemical synthesis

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