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Long pyrimidine tracts of L-cell DNA: localization to repeated DNA.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1974 Aug; Vol. 71 (8), pp. 2992-5. - Publication Year :
- 1974
-
Abstract
- Like HeLa DNA, L-cell DNA contains a significant number of unexpectedly long pyrimidine tracts. 1.3% of the thymidine residues of L-cell DNA are found in these long polypyrimidine tracts. Analysis of L-cell DNA fractions with different rates of reassociation indicates that polypyrimidine tracts are associated with "repeated" DNA. Longer pyrimidine tracts appear to have a higher repetition frequency than shorter tracts, and some may be repeated as many as 5 x 10(4) times in L-cell DNA.
- Subjects :
- Animals
Base Sequence
Chromatography
DNA, Neoplasm metabolism
Electrophoresis, Polyacrylamide Gel
Female
HeLa Cells analysis
Humans
Hydroxyapatites
Mice
Nucleic Acid Denaturation
Nucleic Acid Renaturation
Oligonucleotides isolation & purification
Thymidine metabolism
Tritium
DNA, Neoplasm analysis
L Cells analysis
Polynucleotides analysis
Pyrimidine Nucleotides analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 71
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 4528633
- Full Text :
- https://doi.org/10.1073/pnas.71.8.2992