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Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis.
- Source :
-
Annals of surgery [Ann Surg] 1979 Apr; Vol. 189 (4), pp. 503-8. - Publication Year :
- 1979
-
Abstract
- The effect of colonic hyperplasia produced by resection of the distal third of the small bowel (DSBR) on the development of chemical carcinogenesis of the colon by dimethylhydrazine (DMH) was tested in rats. For the most part the amounts of RNA and DNA in the small bowel were the same with the combined treatments as with either one alone; quantities of nucleic acids tended to increase only in transverse and distal colon. After 37 weeks the number of neoplasms per rat was increased six-fold by combining DSBR with DMH. Neoplasms were spread throughout the colon after combined treatment as opposed to the ascending colong after DMH alone. Postresectional hyperplasia appears to increase the incidence and distribution of colon tumors.
- Subjects :
- Animals
Colon pathology
Colonic Neoplasms mortality
Colonic Neoplasms pathology
DNA biosynthesis
Hyperplasia
Intestinal Mucosa pathology
Male
Neoplasms, Experimental chemically induced
Neoplasms, Experimental mortality
Neoplasms, Experimental pathology
RNA biosynthesis
Rats
Cocarcinogenesis
Colonic Neoplasms chemically induced
Dimethylhydrazines administration & dosage
Ileum surgery
Methylhydrazines administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4932
- Volume :
- 189
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annals of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 443906