Increased antitumor activity of cyclophosphamide (Endoxan) following pretreatment with inducer of drug-metabolizing enzymes (cytochrome P-450).

Authors :: Oira S
Maezawa S
Irinoda Y
Watanabe K
Kitada K
Source :: The Tohoku journal of experimental medicine [Tohoku J Exp Med] 1974 Sep; Vol. 114 (1), pp. 55-60.
Publication Year :: 1974

Subjects :: Alkylation
Animals
Chloramphenicol pharmacology
Cyclophosphamide metabolism
Cytochrome P-450 Enzyme Inhibitors
Cytochromes metabolism
Drug Interactions
Enzyme Induction
Male
Microsomes, Liver metabolism
Phenobarbital pharmacology
Rats
Spectrophotometry
Cyclophosphamide pharmacology
Cytochrome P-450 Enzyme System metabolism

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