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Conversion of allyl alcohol into acrolein by rat liver.
- Source :
-
The Biochemical journal [Biochem J] 1972 Aug; Vol. 128 (5), pp. 1103-7. - Publication Year :
- 1972
-
Abstract
- 1. Acrolein was detected in rat liver suspensions incubated in the presence of allyl alcohol and allyl formate. Acrolein was determined by condensation of the distilled aldehyde with semicarbazide, followed by spectrophotometric measurement of the semicarbazone at 257nm and identification by paper chromatography. 2. The transformation of allyl alcohol into acrolein occurred in the presence of NAD(+). Inhibitors of rat liver alcohol dehydrogenase inhibited the reaction. 3. It is suggested that the hepatotoxic actions of allyl alcohol and of allyl formate on rat liver are related to their conversion into acrolein.
- Subjects :
- Alcohol Oxidoreductases
Animals
Chromatography, Paper
Formates metabolism
Liver enzymology
Male
Microsomes, Liver metabolism
Mitochondria, Liver metabolism
NAD
NADP
Rats
Semicarbazones biosynthesis
Spectrophotometry
Alcohols metabolism
Aldehydes biosynthesis
Allyl Compounds metabolism
Liver metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0264-6021
- Volume :
- 128
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Biochemical journal
- Publication Type :
- Academic Journal
- Accession number :
- 4404964
- Full Text :
- https://doi.org/10.1042/bj1281103