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Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1.
- Source :
-
Journal of virology [J Virol] 1973 Aug; Vol. 12 (2), pp. 209-17. - Publication Year :
- 1973
-
Abstract
- The in vitro transformation of hamster embryo fibroblasts by herpes simplex virus type 1 (HSV-1) after exposure of the virus to UV irradiation is described. Cell transformation was induced by 2 out of 12 strains of HSV-1 that were tested for transforming potential. Cells transformed by the KOS strain of HSV-1 were not oncogenic when injected into newborn Syrian hamsters. However, cells transformed by HSV-1 strain 14-012 induced tumors in 47% of the newborn hamsters injected. HSV-specific antigens were found in the cytoplasm of cells transformed by both virus strains. Sera from tumor-bearing hamsters contained HSV-1- and HSV-2-neutralizing antibodies as well as antibodies which reacted specifically with HSV antigens by the indirect immunofluorescence technique. Hamster oncornavirus antigens were not detected by immunofluorescence methods. These observations represent the first evidence of the oncogenic potential of HSV-1.
- Subjects :
- Animals
Antibodies, Viral isolation & purification
Antigens, Viral isolation & purification
Cricetinae
Culture Techniques
Cytoplasm immunology
Fibroblasts
Fluorescent Antibody Technique
Humans
Kidney
Neoplasms, Experimental blood
Neoplasms, Experimental etiology
Neutralization Tests
Rabbits
Radiation Effects
Simplexvirus immunology
Simplexvirus radiation effects
Ultraviolet Rays
Viral Plaque Assay
Cell Transformation, Neoplastic
Simplexvirus growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 4355928
- Full Text :
- https://doi.org/10.1128/JVI.12.2.209-217.1973