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An improved cell fractionation procedure for the preparation of rat liver membrane-bound ribosomes.

Authors :
Adelman MR
Blobel G
Sabatini DD
Source :
The Journal of cell biology [J Cell Biol] 1973 Jan; Vol. 56 (1), pp. 191-205.
Publication Year :
1973

Abstract

A cell fractionation procedure is described which allows the preparation from rat liver of a rough microsome population containing almost 50% of the membrane-bound ribosomes of the tissue. The fraction is not contaminated with free ribosomes or smooth microsomes, and, by various other criteria, is suitable for studies of ribosome-membrane interaction.

Details

Language :
English
ISSN :
0021-9525
Volume :
56
Issue :
1
Database :
MEDLINE
Journal :
The Journal of cell biology
Publication Type :
Academic Journal
Accession number :
4345164
Full Text :
https://doi.org/10.1083/jcb.56.1.191