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Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma.
- Source :
-
Journal of lipid research [J Lipid Res] 1972 May; Vol. 13 (3), pp. 356-63. - Publication Year :
- 1972
-
Abstract
- Heparin-released triglyceride lipase from three sources, adipose tissue, liver, and postheparin plasma, was compared. Heparin-released triglyceride lipase from liver differed in several major respects from that in adipose tissue. These differences included response to inhibitors and to high density lipoprotein in the incubation media. Heparin-released triglyceride lipase from liver, when compared with that from adipose tissue, was relatively inactive against lipoprotein substrates. The triglyceride lipase from postheparin plasma exhibited properties more like those of liver. These studies raise the possibility that triglyceride lipase in postheparin plasma may be heterogeneous and that levels of the enzyme in postheparin plasma may not accurately reflect the capacity for clearance of triglyceride from the plasma.
- Subjects :
- Adipose Tissue drug effects
Animals
Carbon Isotopes
Chylomicrons
Diphosphates pharmacology
Epididymis enzymology
Heparin pharmacology
Humans
Lipoprotein Lipase
Lipoproteins, HDL pharmacology
Liver drug effects
Male
Methods
Osmolar Concentration
Perfusion
Protamines pharmacology
Rats
Sodium Chloride pharmacology
Triglycerides
Triolein
Adipose Tissue enzymology
Lipase antagonists & inhibitors
Lipase blood
Lipase isolation & purification
Liver enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2275
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of lipid research
- Publication Type :
- Academic Journal
- Accession number :
- 4337156