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The pathology of adrenocortical neoplasia: a correlated structural and functional approach to the diagnosis of malignant disease.
- Source :
-
Human pathology [Hum Pathol] 1979 Mar; Vol. 10 (2), pp. 137-54. - Publication Year :
- 1979
-
Abstract
- The structural and functional characteristics of nine functioning adrenocortical tumors (four adenomas and five carcinomas) causing Cushing's syndrome or virilization were studied. All tumors that we considered to show histologic evidence of malignant disease and that subsequently metastasized or recurred also showed in cell culture at least one significant functional or behavioral difference from benign tumors. No single defect was common to all carcinomas, but predominant changes included secretion of precursor steroids, such as 11-deoxycortisol (S) and a blunted or absent response to ACTH. All adenomase examined were normal in these respects in comparison with nondiseased cortical cells in culture. In carcinomas whose functions deviated only minimally from normal the presence of highly differentiated ultrastructural characteristics did not, however, confer a better prognosis.
- Subjects :
- Adenoma pathology
Adrenal Cortex Neoplasms complications
Adrenal Cortex Neoplasms diagnosis
Adrenal Cortex Neoplasms ultrastructure
Adult
Aged
Carcinoma pathology
Cells, Cultured
Cushing Syndrome etiology
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Adrenal Cortex Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0046-8177
- Volume :
- 10
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 422187
- Full Text :
- https://doi.org/10.1016/s0046-8177(79)80004-0