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Biosynthesis of a vasotocin-like peptide in cell cultures from pineal glands of human fetuses.
- Source :
-
Science (New York, N.Y.) [Science] 1973 Sep 28; Vol. 181 (4106), pp. 1252-3. - Publication Year :
- 1973
-
Abstract
- Cultured cells from pineal glands of human fetuses release into their media a substance that has antidiuretic and hydroosmotic activities. The ratio of these activities as well as their susceptibility to tryptic digestion, specific oxidative inactivation by tyrosinase, and reductive inactivation by sodium thioglycollate, indicates the presence of a basic peptide, presumably identical with arginine vasotocin. The total amount of this peptide released into the culture media during 38 days of incubation is about ten times greater than the amount contained in nonincubated pineal glands from fetuses of the same age, strongly suggesting that fetal ependymal cells from the pineal gland can synthesize in vitro a peptide similar to arginine vasotocin.
- Subjects :
- Animals
Anura
Arginine
Biological Assay
Catechol Oxidase pharmacology
Cells, Cultured
Diuresis drug effects
Female
Fetus
Gestational Age
Humans
Male
Osmosis drug effects
Pineal Gland embryology
Rana temporaria
Rats
Trypsin pharmacology
Urinary Bladder drug effects
Uterus drug effects
Vasotocin antagonists & inhibitors
Vasotocin pharmacology
Pineal Gland metabolism
Vasotocin biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 181
- Issue :
- 4106
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 4199284
- Full Text :
- https://doi.org/10.1126/science.181.4106.1252