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Histamine augments leukocyte adenosine 3',5'-monophosphate and blocks antigenic histamine release.

Authors :
Bourne HR
Melmon KL
Lichtenstein LM
Source :
Science (New York, N.Y.) [Science] 1971 Aug 20; Vol. 173 (3998), pp. 743-5.
Publication Year :
1971

Abstract

Extracellular histamine stimulates accumulation of adenosine 3',5'-monophosphate in human leukocytes and prevents antigenic release of histamine from cells of allergic donors. Both effects occur at histamine concentrations that can be achieved by antigenic release of the amine in vitro.

Details

Language :
English
ISSN :
0036-8075
Volume :
173
Issue :
3998
Database :
MEDLINE
Journal :
Science (New York, N.Y.)
Publication Type :
Academic Journal
Accession number :
4105490
Full Text :
https://doi.org/10.1126/science.173.3998.743