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Nerve regeneration and pharmacological suppression of the scar reaction at the suture site. An experimental study on the effect of estrogen-progesterone, methylprednisolone-acetate and cis-hydroxyproline in rat sciatic nerve.
- Source :
-
Scandinavian journal of plastic and reconstructive surgery [Scand J Plast Reconstr Surg] 1985; Vol. 19 (3), pp. 255-60. - Publication Year :
- 1985
-
Abstract
- Pharmacological suppression of the scar reaction was tested as a possible method for improving axonal regeneration after transection and suture of the sciatic nerve of rats. The animals in the experimental groups were systemically treated post-operatively with estrogen-progesterone, methylprednisolone-acetate (Depomedrone) or cis-hydroxyproline. Only in the cis-hydroxyproline treated animals was there a tendency towards a decrease in fibroblastic activity at the suture site after 4 weeks. However, there was no difference in the growth of axons to the distal nerve segment after pharmacological treatment as compared to non-treated animals, when tested 12 weeks post-operatively. The motor nerve conduction velocity was however significantly greater in both the cis-hydroxyproline and the methylprednisolone-acetate groups as compared with the estrogen-progesterone and the control groups. In conclusion, cis-hydroxyproline and also methylprednisolone-acetate may improve the function of regenerating peripheral nerve, while estrogen-progesterone does not seem to have this effect.
- Subjects :
- Animals
Cicatrix etiology
Connective Tissue drug effects
Depression, Chemical
Drug Combinations
Female
Methylprednisolone pharmacology
Methylprednisolone Acetate
Models, Biological
Nerve Fibers drug effects
Neural Conduction drug effects
Rats
Anti-Inflammatory Agents pharmacology
Cicatrix prevention & control
Estrogens pharmacology
Hydroxyproline pharmacology
Methylprednisolone analogs & derivatives
Nerve Regeneration drug effects
Progesterone pharmacology
Sciatic Nerve physiology
Sutures adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0036-5556
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of plastic and reconstructive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 4095510
- Full Text :
- https://doi.org/10.3109/02844318509074512