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Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli.
- Source :
-
Methods and findings in experimental and clinical pharmacology [Methods Find Exp Clin Pharmacol] 1985 Sep; Vol. 7 (9), pp. 473-6. - Publication Year :
- 1985
-
Abstract
- The antagonistic action of aligeron as compared to that of papaverine against different smooth muscle stimuli was studied in experiments in vitro. Three series of experiments were conducted: study of the antagonistic action against experimental spasms of isolated organs caused by different spasmogens; determination of the type of antagonism to adrenaline in isolated vas deferens preparation; and study of the antagonistic action against vasoconstrictor effects of noradrenaline and adrenaline in isolated perfused rabbit renal artery. Aligeron showed a broad spectrum of antagonistic action against different spasmogens in different isolated organs. Its effect was more pronounced than that of papaverine. The antagonism was of the non-competitive type. The experiments on isolated perfused rabbit artery showed the antagonistic action of aligeron against the vasoconstrictor effects of noradrenaline and adrenaline. The results suggest the clinical use of aligeron in conditions associated with increased release of these vasoactive substances.
- Subjects :
- Animals
Cinnarizine pharmacology
Epinephrine antagonists & inhibitors
Guinea Pigs
In Vitro Techniques
Male
Muscle Contraction drug effects
Norepinephrine antagonists & inhibitors
Rabbits
Rats
Cinnarizine analogs & derivatives
Muscle, Smooth drug effects
Muscle, Smooth, Vascular drug effects
Papaverine pharmacology
Vasoconstrictor Agents antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0379-0355
- Volume :
- 7
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Methods and findings in experimental and clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 4079597