Plasma lipoprotein levels and in vitro cholesterol synthesis by cells in human blood.

This study has measured plasma lipoprotein lipid levels and the in vitro rate of cholesterol synthesis from [2(-14)C]acetate by mononuclear leukocytes in blood from normolipidemic subjects and two patients with Tangier disease. The rate of cholesterol synthesis in blood was related inversely to plasma levels of HDL cholesterol in the normolipidemic subjects. This relationship was mainly due to a similar correlation in the women. The rate of blood cholesterol synthesis was raised in a woman with Tangier disease, which is consistent with the above correlation, but not in a man with this disease. We suggest that this correlation reflects an association between plasma HDL cholesterol levels and whole-body sterol synthesis.