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Immune hemolytic anemia associated with probenecid.

Authors :
Sosler SD
Behzad O
Garratty G
Lee CL
Postoway N
Khomo O
Source :
American journal of clinical pathology [Am J Clin Pathol] 1985 Sep; Vol. 84 (3), pp. 391-4.
Publication Year :
1985

Abstract

Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the patient's RBCs, with and without the presence of drug, were nonreactive. Upon the discontinuation of probenecid, the patient's hemoglobin level improved steadily. We believe this to be the first reported case of immune hemolytic anemia associated with probenecid.

Details

Language :
English
ISSN :
0002-9173
Volume :
84
Issue :
3
Database :
MEDLINE
Journal :
American journal of clinical pathology
Publication Type :
Academic Journal
Accession number :
4036870
Full Text :
https://doi.org/10.1093/ajcp/84.3.391