[Effect of blood components on the stability of liposomes].

The human blood plasma is studied for its effect on the outlet of different substances from lecithin liposomes. It is shown that in the presence of the whole blood the permeability of liposomal membrane for the low-molecular weight compounds increases sharply. Blood plasma proteins play a key role in this process but the influence of albumin, gamma-globulins, fibrinogen as well as of serum lipases is rather insignificant. An increase in the rate of outlet of substances in the presence of blood plasma depends on their molecular weight and may be explained by the formation of dynamic defects or pores of definite size in the liposomal membrane. The formation of these defects (pores) is supposed to proceed due to insertion of blood plasma proteins into the phospholipid matrix of liposomes.