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Total body sodium in immature spontaneously hypertensive and Wistar Kyoto rats.
- Source :
-
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 1985 May-Jun; Vol. 12 (3), pp. 315-8. - Publication Year :
- 1985
-
Abstract
- Total body sodium of male and female spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats was estimated weekly during the first 8 weeks of life by measuring exchangeable sodium (ENa). Blood pressure and sodium intake was measured from weeks 4 to 8. SHR had significantly higher blood pressure and sodium intake than WKY from 4 to 8 weeks of age. ENa was higher in SHR than WKY throughout the first 8 weeks of life. Relative sodium retention was observed in SHR during weeks 5 to 8 despite a significant rise in SHR blood pressure and fall in sodium intake. These findings suggest a change in the renal pressure/natriuresis relationship at this age in the SHR.
Details
- Language :
- English
- ISSN :
- 0305-1870
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical and experimental pharmacology & physiology
- Publication Type :
- Academic Journal
- Accession number :
- 4028518
- Full Text :
- https://doi.org/10.1111/j.1440-1681.1985.tb02652.x