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Antagonism by some beta-adrenoceptor-blocking agents to cholinergic stimulation of skeletal muscle in vitro.
- Source :
-
Pharmacology [Pharmacology] 1979; Vol. 18 (6), pp. 319-26. - Publication Year :
- 1979
-
Abstract
- Antiacetylcholine activity some beta-adrenoceptor-blocking drugs was investigated using isolated guinea pig cremaster muscle and frog fectus abdominis muscle. On the cremaster muscle, the antagonism to acetylcholine was non competitive in K0 1313, (+/-)-INPEA and (--)-INPEA, competitive in (+)-INPEA and functional in practolol; All three INPEA isomers, practolol and propranolol behaved as noncompetitive antagonists of acetylcholine on frog rectus muscle. Caffeine-induced contractions of this muscle were partially inhibited by propranolol but not by the other drugs. It is suggested that the beta-adrenoceptor-blocking drugs produce their antiacetylcholine action by interaction with sites on the muscle which are different from the cholinceptor, and which vary between compounds and species.
- Subjects :
- Acetylcholine metabolism
Animals
Anura
Ethanolamines pharmacology
Guinea Pigs
Mesylates pharmacology
Muscle Contraction drug effects
Nitriles pharmacology
Practolol pharmacology
Propranolol pharmacology
Rana pipiens
Sotalol pharmacology
Adrenergic beta-Antagonists pharmacology
Muscles drug effects
Neuromuscular Junction drug effects
Receptors, Cholinergic drug effects
Synaptic Transmission drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0031-7012
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 40268
- Full Text :
- https://doi.org/10.1159/000137272