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Bone mineral density in patients using aromatase inhibitors: a clinical, nutritional, and quality of life assessment.
Bone mineral density in patients using aromatase inhibitors: a clinical, nutritional, and quality of life assessment.
- Source :
-
Brazilian oral research [Braz Oral Res] 2025 Feb 21; Vol. 39, pp. e023. Date of Electronic Publication: 2025 Feb 21 (Print Publication: 2025). - Publication Year :
- 2025
-
Abstract
- The use of aromatase inhibitors (AIs) leads to an imbalance in bone remodeling and can cause osteoporosis. This study aimed to identify clinical, periodontal, nutritional, and biochemical determinants of bone mineral density (BMD) changes in patients using AIs. The sample consisted of 40 women using AIs and 32 controls. BMD was assessed by dual X-ray absorptiometry (DXA). Data on nutritional, anthropometric, oral and periodontal status, and oral health-related quality of life (OHRQoL) were collected. Cytokines and adipokines were quantified in saliva and serum. Thirty-nine of the 72 women had low BMD, with a similar distribution in the control and AIs groups. BMD was lower in older women using AIs (p = 0.009) and in smokers (p = 0.034). Anthropometric assessment demonstrated that women with low BMD who used AIs had lower weight (p = 0.028). Although the frequency of periodontitis was similar in all groups, higher IL-6 (p = 0.004), IL-1β (p = 0.002), and IL-33 (p = 0.006) levels were associated with poor periodontal status. Women who used AIs were 1.18 times more likely to report better OHRQoL than controls. While advanced age, smoking, and lower weight are factors associated with low BMD, the use of antiresorptive agents was a protective factor for maintaining BMD in women using AIs.
- Subjects :
- Humans
Female
Middle Aged
Case-Control Studies
Aged
Reference Values
Cytokines analysis
Cytokines blood
Statistics, Nonparametric
Saliva chemistry
Adipokines blood
Adipokines analysis
Cross-Sectional Studies
Adult
Age Factors
Osteoporosis
Bone Density drug effects
Quality of Life
Aromatase Inhibitors therapeutic use
Absorptiometry, Photon
Nutritional Status drug effects
Nutritional Status physiology
Oral Health statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1807-3107
- Volume :
- 39
- Database :
- MEDLINE
- Journal :
- Brazilian oral research
- Publication Type :
- Academic Journal
- Accession number :
- 40008732
- Full Text :
- https://doi.org/10.1590/1807-3107bor-2025.vol39.023