GSDM family and glioma.

Authors :: Kaczor S
Szewczyk-Roszczenko O
Pawlak D
Hermanowicz A
Hermanowicz JM
Source :: Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2025 Feb 09; Vol. 1880 (2), pp. 189283. Date of Electronic Publication: 2025 Feb 09.
Publication Year :: 2025
Publisher :: Ahead of Print
Abstract: Biomarkers play a central role in diagnosing, prognosis, and therapeutic management of gliomas, a diverse group of malignancies arising from glial cells in the brain and spinal cord. Among the various emerging biomarkers, the gasdermin protein family has attracted attention for its involvement in pyroptosis. Understanding the expression and function of GSDM in gliomas may provide new insights into tumor behavior and new avenues for therapeutic intervention. This review discusses the GSDM family's significance as a glioma biomarker, explores its dual role in tumor suppression, and highlights its potential utility in clinical practice as a novel target for glioma therapy.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2025. Published by Elsevier B.V.)