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Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice.
Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice.
- Source :
-
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie [Res Exp Med (Berl)] 1985; Vol. 185 (2), pp. 151-62. - Publication Year :
- 1985
-
Abstract
- The combined effects of ethinyl estradiol (EE) (0.5 micrograms/g s.c. once daily for 4 days) and tetracycline (TC) or doxycycline (DC) (50 micrograms/g i.v.) on liver weight and water content, serum transaminases, alkaline phosphatase, urea, triglycerides, and cholesterol as parameters of various liver functions were investigated in mice. It became apparent that depending on the parameter tested synergistic and antagonistic effects may occur, e.g., synergistic effects were observed with the serum transaminases and liver cholesterol; antagonistic effects were seen with the serum urea and serum cholesterol.
Details
- Language :
- English
- ISSN :
- 0300-9130
- Volume :
- 185
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
- Publication Type :
- Academic Journal
- Accession number :
- 3992059
- Full Text :
- https://doi.org/10.1007/BF01854901