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Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice.

Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice.

Authors :
Böcker R
Estler CJ
Feiner C
Hopf G
Schrader K
Schramm W
Source :
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie [Res Exp Med (Berl)] 1985; Vol. 185 (2), pp. 151-62.
Publication Year :
1985

Abstract

The combined effects of ethinyl estradiol (EE) (0.5 micrograms/g s.c. once daily for 4 days) and tetracycline (TC) or doxycycline (DC) (50 micrograms/g i.v.) on liver weight and water content, serum transaminases, alkaline phosphatase, urea, triglycerides, and cholesterol as parameters of various liver functions were investigated in mice. It became apparent that depending on the parameter tested synergistic and antagonistic effects may occur, e.g., synergistic effects were observed with the serum transaminases and liver cholesterol; antagonistic effects were seen with the serum urea and serum cholesterol.

Details

Language :
English
ISSN :
0300-9130
Volume :
185
Issue :
2
Database :
MEDLINE
Journal :
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
Publication Type :
Academic Journal
Accession number :
3992059
Full Text :
https://doi.org/10.1007/BF01854901