[Detection of autoantibodies to blood coagulation factors by the passive hemagglutination reaction and by an immunoenzyme (ELISA) method].

Plasma of healthy persons and intact animals contains antibodies to blood coagulation factors IIa and Xa of autologous origin demonstrated by passive hemagglutination and ELISA. During fibrin formation, autoantibodies are bound and thus are not detectable in the serum. The importance of the facts described for hemostasis control is discussed.