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The Fit Older Adult with Acute Myeloid Leukemia: Clinical Challenges to Providing Evidence-Based Frontline Treatment.

Authors :
Abedin SM
Uy GL
Michaelis LC
Source :
Blood [Blood] 2025 Jan 24. Date of Electronic Publication: 2025 Jan 24.
Publication Year :
2025
Publisher :
Ahead of Print

Abstract

Recent advances in acute myeloid leukemia (AML) come from studies investigating younger (age<60 years) adults or older (ageā‰„75 years) or less fit adults. Uncertainty exists for the management of otherwise healthy adults with AML in their 60s and 70s, which also represents a significant proportion of AML cases. We discuss current considerations in older, fit adults with AML including determination of fitness, what factors beyond fitness should be assessed, and finally what challenges and innovations lie ahead to improve outcomes for these patients.<br /> (Copyright © 2025 American Society of Hematology.)

Details

Language :
English
ISSN :
1528-0020
Database :
MEDLINE
Journal :
Blood
Publication Type :
Academic Journal
Accession number :
39854694
Full Text :
https://doi.org/10.1182/blood.2024026004