Umbrella Reviews: A methodological guide.

Aim: This paper aims to explore the significance of umbrella reviews as a methodological advancement in evidence synthesis, emphasizing their role in aggregating data from multiple systematic reviews and their impact on evidence-based practice and policy-making.
Methods and Results: The paper examines the evolution of systematic reviews and meta-analyses, highlighting the emergence of umbrella reviews as a comprehensive synthesis method. It details the key steps involved in conducting an umbrella review, including literature searches, study selection, quality appraisal, and data synthesis. Various types of umbrella reviews are discussed, along with the integration of advanced methodologies and interdisciplinary approaches that enhance their effectiveness.
Conclusion: Umbrella reviews have become an essential tool in evidence synthesis, offering a higher-level aggregation of systematic reviews to inform decision-making in clinical and policy contexts. Their evolving methodologies, combined with interdisciplinary approaches, make them crucial in shaping the future of evidence-based practice globally.
(© The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.)