N 6 -Methylandenosine-related lncRNAs as potential biomarkers for predicting prognosis and the immunotherapy response in pancreatic cancer.

Emerging evidence has shown that the N ⁶ -methyladenosine (m ⁶ A) modification of RNA plays key roles in tumorigenesis and the progression of various cancers. However, the potential roles of the m ⁶ A modification of long noncoding RNAs (lncRNAs) in pancreatic cancer (PaCa) are still unknown. To analyze the prognostic value of m ⁶ A-related lncRNAs in PaCa, an m6A-related lncRNA signature was constructed as a risk model via Pearson's correlation and univariate Cox regression analyses in The Cancer Genome Atlas (TCGA) database. The tumor microenvironment (TME), tumor mutation burden, and drug sensitivity of PaCa were investigated by m ⁶ A-related lncRNA risk score analyses. We established an m ⁶ A-related risk prognostic model consisting of five lncRNAs, namely, LINC01091, AC096733.2, AC092171.5, AC015660.1, and AC005332.6, which not only revealed significant differences in immune cell infiltration associated with the TME between the high-risk and low-risk groups but also predicted the potential benefit of immunotherapy for patients with PaCa. Drugs such as WZ8040, selumetinib, and bortezomib were also identified as more effective for high-risk patients. Our results indicate that the m ⁶ A-related lncRNA risk model could be an independent prognostic indicator, which may provide valuable insights for identifying therapeutic approaches for PaCa.
Competing Interests: Declarations. Ethics approval and consent to participate: All human specimens were collected in accordance with the protocol approved by the Ethics Committees of Zhongshan Hospital (Xiamen) of Fudan University (B2024-018) and all the study subjects provided written informed consent to participate. Consent for publication: Not applicable. Competing interests: The authors have no financial interest.
(© 2025. The Author(s).)